This page is to help support those with Pyrroluria or family/friends with pyrrole disorder. HPL is a biomarker for oxidative stress and is neurotoxic.
This page is OPEN, but for a CLOSED group, please visit and invite yourself to PYRROLE AUSTRALIA GROUP Pyrrol disorder, also known as pyroluria, kryptopyrroluria or kryptopyrrole disorder is a biochemical imbalance involving an abnormality in hemoglobin synthesis that can be purely genetic or acquired through environmental and emotional stressors. Pyrrol disorder is caused by the overproduction of
hydroxyhempyrrolin (HPL). The HPL binds zinc and B6 preventing their use by the body and causing excretion in the urine and hair. Stress of any kind will increases production of pyrrols/HPL which in turn decreases zinc and B6. The main biochemical features are of severe zinc and B6 deficiency. Zinc is essential for 100’s of processes in the body and is particularly important for healing, immune function, digestion, neurotransmitter activation, physical growth, memory, insulin sensitivity, and control of blood sugars, DNA replication and more....
Zinc and B6 are essential for production of neurotransmitters such as serotonin (our happy hormone), melatonin (our sleep hormone), GABA (our relaxation hormone), and acetyl choline which is important for memory. They are also involved in production of our steroid hormones such as cortisol (our anti-inflammatory, anti-allergy hormone and stress hormone) and the conversion of oils in the body (fat metabolism, liver and gall bladder issues and weight control). The oils EPA/DHA but mostly GLA are found to be low in those with pyrrol disorder and are damaged by oxidative stress/free radicals/toxins created by pyrrole. For more information, testing and support please visit the True Vitality website (see link below) or see more of this article on http://www.truevitality.com.au/articles/pyrrole-disorder/
